The obesity epidemic is fuelling the need to understand how metabolic imbalance drives disease pathogenesis. It is now widely recognized that obesity impacts the immune system and that obesity-associated inflammation contributes to metabolic diseases, such as Type 2 diabetes and cardiovascular disease, as well as cancer.
The aim of this meeting is to bring together researchers from the arenas of immunology and metabolism to discuss the cell types, mediators and pathways that contribute to immunological-metabolic crosstalk and to explore how the immune system might be targeted as a strategy to treat metabolic disease.
Program
(Subject to change)
| Sunday, June 9, 2013 | |
| 13:30 – 15:45 | Registration | Civic Foyer |
| 15.45 – 16.00 | Welcome and Introduction | Civic Ballroom South |
| Session I – Inflammatory Pathways and Metabolic Disease (Session Chair- Gwendalyn Randolph) | Civic Ballroom South |
|
| 16:00 – 16:30 | [K1] Mechanisms of Immunometabolic Integration In Obesity and Diabetes Gökhan Hotamisligil, Harvard Medical School, USA |
| 16:30 – 17:00 | [K2] Metabolic regulation of innate immune signalling
Luke O'Neill, Trinity College Dublin, Ireland |
| 17:00 – 17:15 | [O1] Lipid-induced muscle-macrophage crosstalk contributes to insulin resistance A. Klip, The Hospital for Sick Children, Canada |
| 17:15 - 17:45 | Refreshment break | Simcoe & Dufferin Room and Civic Ballroom North |
| 17:45 - 18:15 | [K3] Inflammation and metabolism
Ruslan Medzhitov, Yale University, USA |
| 18:15 - 18:45 | [K4] Controlling the dynamics of vascular growth by FOXO and sirtuin pathways Matthias Tschöp Technical University Munich, Germany |
| 19:00 – 20:00 | Drinks Reception | Civic Foyer & Garden Waterfall |
| Monday, 10th June | |
| Session II – Metabolic Programming of Systemic Immunity (Session Chair- Marc Donath) | Civic Ballroom South |
|
| 9:00 - 9:45 | [K5] Keynote: The role of macrophages and inflammation in diabetes/insulin resistance Jerrold Olefsky, University of California San Diego, USA |
| 9:45- 10:15 | [K6] Virchow explained: The origin of tumor elicited inflammation and its significance Michael Karin, University of California San Diego, USA |
| 10.15 – 10.45 | [O2] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells S. Arai, The University of Tokyo, Japan |
| 10:45 – 11:15 | Refreshment break | Simcoe & Dufferin Room and Civic Ballroom North |
| 11.15 – 11.45 | [K7] Targeting gp130 to prevent inflammation and promote insulin action Mark Febbraio, Baker IDI Heart and Diabetes Institute, Australia |
| 11:45 – 12:15 | [K8] A reversible mechanism of age-related mitochondrial dysfunction and inflammation David Sinclair, Harvard Medical School, USA |
| 12:00 - 12:15 | Poster Teasers |
| 12:00 - 13:00 | Lunch | Civic Foyer |
| 13:00 - 15:00 | Poster session I Simcoe & Dufferin Room and Civic Ballroom North |
| Session III – Metabolic-immune Cell Interactions (Session Chair - Jerrold Olefsky) |Civic Ballroom South | |
| 15:00 - 15:30 | [K9] Regulatory T Cells Residing in Adipose Tissue Diane Mathis (co-organizer), Harvard Medical School, USA |
| 15:30 - 16:00 | [K10] Innate lymphoid type 2 cells (ILC2) and the cellular architecture of visceral adipose tissue Richard Locksley, University of California San Francisco, USA |
| 16:00 - 16:15 | [O3] Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation T. Deng, The Methodist Hospital Research Institute, USA |
| 16:15 - 16:45 | Refreshments | Simcoe & Dufferin Room and Civic Ballroom North |
| 16:45 - 17:15 | [K11] TBC
Gwendalyn Randolph, Washington University, USA |
| 17:15 - 17:45 | [K12] TBC Bruce Spiegelman, Dana Faber Cancer Center, USA |
| 19.00 | “Meet the Speakers” Dinner (ticket holders only) |
| Tuesday 11th June | |
| Session IV – Nutrients and Gut Microbiota (Session Chair- Diane Mathis) | Civic Ballroom South |
|
| 9:00 - 9:30 | [K13] Diet rapidly and reproducibly alters the human gut microbiome Peter Turnbaugh, Harvard University, USA |
| 9:30 - 10:00 | [K14] Pathways in microbe-induced obesity Martin Blaser, New York University, USA |
| 10:00 - 10:15 | [O4] Diet-microbiota interactions and their implication for host metabolism R. Caesar, Gothenburg University, Sweden |
| 10:15 – 10:45 | Refreshment break | Simcoe & Dufferin Room and Civic Ballroom North |
| 10:45 - 11:15 | [K15] TBC Richard Flavell, Yale University, USA |
| 11:15 - 11:30 | [O5] A SIRT1-RelB Checkpoint Reprograms Mitochondrial Bioenergetics during Acute Inflammation T.F. Liu, Wake Forest University School of Medicine, USA |
| 11:30 – 11.45 | Poster Teasers |
| 12:00 - 13:00 | Lunch | Civic Foyer |
| 13:00 - 15:00 | Poster Session II | Simcoe & Dufferin Room and Civic Ballroom North |
| Session V – Immunotherapy (Session Chair- Mark Febbraio) | Civic Ballroom South |
|
| 15:00 - 15:30 | [K16] Islet inflammation in type 2 diabetes: physiology, pathology, therapy Marc Donath (co-organizer), University Hospital Basel, Switzerland |
| 15:30 - 16:00 | [K17] TBC Stephen Shoelson, Joslin Diabetes Center, USA |
| 16:00 – 16:15 | [O6] AMP-activated protein kinase (AMPK) links lipid metabolism with innate immunity and the therapeutic effects of salicylate M.D. Fullerton, McMaster University, Canada |
| 16:15 - 16:45 | Refreshment Break | Simcoe & Dufferin Room and Civic Ballroom North |
| 16:45 - 17:15 | [K18] Islet Autoimmunity In Type 2 Diabetes- More Than Just LADA Jerry Palmer University of Washington, USA |
| 17:15 - 17:45 | [K19] TBC Dhavalkumar Patel, Novartis Institutes for BioMedical Research, Switzerland |
| 17.45 – 18.00 | [O7] Lipid uptake by adipose tissue macrophages improves glucose tolerance in obese mice M. Aouadi, UMass Medical School, USA |
| 18.00 – 18:15 | Closing remarks | Civic Ballroom South |
